Structure of PDB 7r4f Chain M

Receptor sequence
>7r4fM (length=453) Species: 9913 (Bos taurus) [Search protein sequence]
MLKYIIPTIMLMPLTWLSKNNMIWVNSTAHSLLISFTSLLLMNQFGDNSL
NFSLLFFSDSLSTPLLILTMWLLPLMLMASQHHLSKENLTRKKLFITMLI
SLQLFLIMTFTAMELILFYILFEATLVPTLIIITRWGNQGLYFLFYTLAG
SLPLLVALIYIQNTVGSLNFLMLQYWVQPVHNSWSNVFMWLACMMAFMVK
MPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMLRITLILNPMTDF
MAYPFIMLSLWGMIMTSSICLRQTDLKSLIAYSSVSHMALVIVAILIQTP
WSYMGATALMIAHGLTSSMLFCLANSNYERIHSRTMILARGLQTLLPLMA
TWWLLASLTNLALPPTINLIGELFVVMSTFSWSNITIILMGVNMVITALY
SLYMLIMTQRGKYTYHINNISPSFTRENALMSLHILPLLLLTLNPKIILG
PLY
3D structure
PDB7r4f Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
ChainM
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide M W190 S191 F194 W184 S185 F188
Gene Ontology
Molecular Function
GO:0003954 NADH dehydrogenase activity
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0048039 ubiquinone binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0009060 aerobic respiration
GO:0015990 electron transport coupled proton transport
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0042773 ATP synthesis coupled electron transport
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0045271 respiratory chain complex I

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7r4f, PDBe:7r4f, PDBj:7r4f
PDBsum7r4f
PubMed36701435
UniProtP03910|NU4M_BOVIN NADH-ubiquinone oxidoreductase chain 4 (Gene Name=MT-ND4)

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