Structure of PDB 7pfc Chain M

Receptor sequence
>7pfcM (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
ARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLP
NIQAVLLPK
3D structure
PDB7pfc Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
ChainM
Resolution6.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna M R11 A14 K15 R17 R20 G28 R29 R32 R42 R77 R2 A5 K6 R8 R11 G19 R20 R23 R33 R68
BS02 dna M R11 K13 H31 R35 R42 V43 G44 A45 T76 R77 R2 K4 H22 R26 R33 V34 G35 A36 T67 R68
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:7pfc, PDBe:7pfc, PDBj:7pfc
PDBsum7pfc
PubMed35581345
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

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