Structure of PDB 7o4i Chain M

Receptor sequence
>7o4iM (length=308) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
RGPNLNIVLTCPECKVYPPKIVERFSEGDVVCALCGLVLSDKLVDRVGEA
SNPLLDGNNLSTRIGKGETTDMRFTKELNKAQGKNVMDKKDNEVQAAFAK
ITMLCDAAELPKIVKDCAKEAYKLCHDEKTLKGKSMESIMAASILIGCRR
AEVARTFKEIQSLIHVKTKEFGKTLNIMKNILRGKSEDGKIDTDNMSGAQ
NLTYIPRFCSHLGLPMQVTTSAEYTAKKCKEIKEIAGKSPITIAVVSIYL
NILLFQIPITAAKVGQTLQVTEGTIKSGYKILYEHRDKLVDPQLIANGVV
SLDNLPGV
3D structure
PDB7o4i Structure of RNA polymerase II pre-initiation complex at 2.9 angstrom defines initial DNA opening.
ChainM
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna M K112 K164 G165 K166 G271 K272 T276 T305 T308 K80 K132 G133 K134 G237 K238 T242 T271 T274
BS02 ZN M C24 C27 C45 C48 C11 C14 C32 C35
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0001139 RNA polymerase II complex recruiting activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0017025 TBP-class protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006352 DNA-templated transcription initiation
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0010467 gene expression
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0070897 transcription preinitiation complex assembly
Cellular Component
GO:0005634 nucleus
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7o4i, PDBe:7o4i, PDBj:7o4i
PDBsum7o4i
PubMed34133942
UniProtP29055|TF2B_YEAST Transcription initiation factor IIB (Gene Name=SUA7)

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