Structure of PDB 7m5c Chain M

Receptor sequence
>7m5cM (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
SEEQVAQDTEEVFRSYVFYRHQQEQADPEMVTSTMGQVGRQLAIIGDDIN
RRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGY
RLALHVYQHGLTGFLGQVTRFVVDFMLHHSIARWIAQRGGWVAALNLCN
3D structure
PDB7m5c Structural basis of BAK activation in mitochondrial apoptosis initiation.
ChainM
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide M I85 R88 Y89 E92 F93 M96 H99 I114 L118 N124 G126 R127 F134 L183 N185 I49 R52 Y53 E56 F57 M60 H63 I78 L82 N88 G90 R91 F98 L147 N149
BS02 CU M H141 H145 H105 H109
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7m5c, PDBe:7m5c, PDBj:7m5c
PDBsum7m5c
PubMed35017502
UniProtQ16611|BAK_HUMAN Bcl-2 homologous antagonist/killer (Gene Name=BAK1)

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