Structure of PDB 7kzs Chain M

Receptor sequence
>7kzsM (length=370) Species: 9606 (Homo sapiens) [Search protein sequence]
MAVTEASLLRQCPLLLPQNRSKTVYEGFISAQGRDFHLRIVLPEDLQLKN
ARLLCSWQLRTILSGYHRIVQQRMQHSPDLMSFMMELKMLLEVALKNRQE
LYALPPPPQFYSSLIEEIGTLGWDKLVYADTCFSTIKLKAEDASGREHLI
TLKLKAKYPAESPDYFVDFPVPFCASWTPQSSLISIYSQFLAAIESLKAF
WDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTMLPE
CFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEK
SDFTMDCGICYAYQLDGTIPDQVCDNSQCGQPFHQICLYEWLRGLLTSRQ
SFNIIFGECPYCSKPITLKM
3D structure
PDB7kzs Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
ChainM
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN M C307 H334 C337 C307 H334 C337
BS02 ZN M C324 C329 C359 C362 C324 C329 C359 C362
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0006974 DNA damage response
GO:0007276 gamete generation
GO:0016567 protein ubiquitination
GO:0036297 interstrand cross-link repair
GO:0042127 regulation of cell population proliferation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016604 nuclear body
GO:0043231 intracellular membrane-bounded organelle
GO:0043240 Fanconi anaemia nuclear complex

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Cellular Component
External links
PDB RCSB:7kzs, PDBe:7kzs, PDBj:7kzs
PDBsum7kzs
PubMed33686268
UniProtQ9NW38|FANCL_HUMAN E3 ubiquitin-protein ligase FANCL (Gene Name=FANCL)

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