Structure of PDB 7abn Chain M

Receptor sequence

>7abnM (length=494) Species: 287 (Pseudomonas aeruginosa)

MNRSALDFRHFVDHLRRQGDLVDVHTEVDANLEIGAITRRVYERRAPAPL
FHNIRDSLPGARVLGAPAGLRADRARAHSRLALHFGLPEHSGPRDIVAML
RAAMRAEPIAPRRLERGPVQENVWLGEQVDLTRFPVPLLHEQDGGRYFGT
YGFHVVQTPDGSWDSWSVGRLMLVDRNTLAGPTIPTQHIGIIREQWRRLG
KPTPWAMALGAPPAALAAAGMPLPEGVSEAGYVGALVGEPVEVVRTQTNG
LWVPANTEIVLEGEISLDETALEGPMGEYHGYSFPIGKPQPLFHVHALSF
RDQPILPICVAGTPPEENHTIWGTMISAQLLDVAQNAGLPVDMVWCSYEA
ATCWAVLSIDVQRLAALGTDAAAFAARVAETVFGSHAGHLVPKLILVGND
IDVTEIDQVVWALATRAHPLHDHFAFPQIRDFPMVPYLDAEDKARGSGGR
LVINCLYPEQFAGQMRAATASFRHAYPTALRRRVEERWSDYGFG

3D structure

• PDB: 7abn Structure and Mechanism of Pseudomonas aeruginosa PA0254/HudA, a prFMN-Dependent Pyrrole-2-carboxylic Acid Decarboxylase Linked to Virulence.
• Chain: M
• Resolution: 1.65 Å

Enzymatic activity

• Enzyme Commision number: 4.1.1.93: pyrrole-2-carboxylate decarboxylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	IMD	M	E278 Y279 N318 W322 M434	E278 Y279 N318 W322 M434
BS02	MN	M	H188 E229	H188 E229
BS03	4LU	M	T150 S167 V168 G169 R170 Q187 H188 A219 G220 M221 P222 C309 N318 W322 H386	T150 S167 V168 G169 R170 Q187 H188 A219 G220 M221 P222 C309 N318 W322 H386

Gene Ontology

Molecular Function

• GO:0008694 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
• GO:0016831 carboxy-lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006744 ubiquinone biosynthetic process
• GO:0009056 catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7abn, PDBe:7abn, PDBj:7abn
• PDBsum: 7abn
• PubMed: 33763291
• UniProt: Q9I6N5|P2CDC_PSEAE Pyrrole-2-carboxylic acid decarboxylase (Gene Name=hudA)