Structure of PDB 6xz7 Chain M

Receptor sequence

>6xz7M (length=136) Species: 83333 (Escherichia coli K-12) [Search protein sequence]

MLQPKRTKFRKMHKGRNRGLAQGTDVSFGSFGLKAVGRGRLTARQIEAAR
RAMTRAVKRQGKIWIRVFPDKPITEKPLAVRMGKGKGNVEYWVALIQPGK
VLYEMDGVPEELAREAFKLAAAKLPIKTTFVTKTVM

3D structure

PDB

6xz7 Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to theE. coli70S ribosome.

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	M	P4 K5 R6 K8 F9 R10 K11 M12 H13 K14 G15 R16 Q22 G23 R40 R44 Q45 A48 R55 K62 W64 R66 F68 D70 K76 A79 X81 M82 G83 K84 G85 K86 K100 A122 K123 P125	P4 K5 R6 K8 F9 R10 K11 M12 H13 K14 G15 R16 Q22 G23 R40 R44 Q45 A48 R55 K62 W64 R66 F68 D70 K76 A79 X81 M82 G83 K84 G85 K86 K100 A122 K123 P125
BS02	rna	M	R16 R18 G19 R38	R16 R18 G19 R38
BS03	rna	M	R50 R55 R59	R50 R55 R59

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6xz7, PDBe:6xz7, PDBj:6xz7
PDBsum	6xz7
PubMed	32144191
UniProt	P0ADY7\|RL16_ECOLI Large ribosomal subunit protein uL16 (Gene Name=rplP)

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