Structure of PDB 6txe Chain M

Receptor sequence

>6txeM (length=475) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGPWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHL
GIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRA
YQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLT
DNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDY
ESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCK
TAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWC
ADRNFTKPQDGDVIAPLITPQKKEW

3D structure

PDB

6txe Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

3.19 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FE	M	H167 H206 D207 D311	H53 H92 D93 D188
BS02	1FZ	M	L150 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374	L36 R50 D93 H101 H119 D188 K189 Y192 D196 R243 Y251
BS03	GTP	M	K116 V117 I118 I136 D137 Q142 R145 F165	K2 V3 I4 I22 D23 Q28 R31 F51
BS04	DTP	M	V156 F157 R372 H376 K377	V42 F43 R249 H253 K254
BS05	DTP	M	R333 R352 K354 N358 K523	R210 R229 K231 N235 K400
BS06	DTP	M	V117 I118 N119	V3 I4 N5
BS07	GTP	M	Y155 V156 R451	Y41 V42 R328

External links

PDB	RCSB:6txe, PDBe:6txe, PDBj:6txe
PDBsum	6txe
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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