Structure of PDB 6txc Chain M

Receptor sequence

>6txcM (length=471) Species: 9606 (Homo sapiens) [Search protein sequence]

MKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNR
FEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFS
HMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEED
ICFIKEQIVGKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQN
NFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHK
VGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIF
LEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLP
KEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPN
RAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRN
FTKPQDGDVIAPLITPQKKEW

3D structure

PDB

6txc Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Chain

Resolution

2.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FE	M	H167 H206 D207 D311	H53 H92 D93 D184
BS02	MG	M	H206 H233	H92 H119
BS03	0KX	M	Q149 R164 D207 H215 H233 D311 K312 Y315 D319 R366 Y374	Q35 R50 D93 H101 H119 D184 K185 Y188 D192 R239 Y247
BS04	GTP	M	K116 V117 I118 D137 R145	K2 V3 I4 D23 R31
BS05	DTP	M	R333 R352 K354 N358 K523	R206 R225 K227 N231 K396
BS06	GTP	M	Y155 V156 V378 R451	Y41 V42 V251 R324
BS07	DTP	M	V156 F157 R372 H376 K377	V42 F43 R245 H249 K250

External links

PDB	RCSB:6txc, PDBe:6txc, PDBj:6txc
PDBsum	6txc
PubMed	32576829
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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