Structure of PDB 6qdv Chain M

Receptor sequence

>6qdvM (length=289) Species: 9606 (Homo sapiens)

ADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRFKK
TEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYY
TQNMEREISNSDGTRPVGMLGKATSAAAALLKLARTTPYYKRNRPHICSF
WVKGECKRGEECPYRHEKPTDPDDPLADQNIKDRYYGINDPVADKLLKRA
STMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRTITVVQRQ
QCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWGRSQ

3D structure

• PDB: 6qdv A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
• Chain: M
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	M	R35 E39 R56 M63 F65 S166 F167 K170 E172 C173 K174 R175 Y181	R18 E22 R39 M46 F48 S149 F150 K153 E155 C156 K157 R158 Y164
BS02	rna	M	K46 R64 K66 K67 E69 T83 C84 G91 L92 R152 Y156 R159 H163 T187 L193 Q196 I198 R201 L213 R216	K29 R47 K49 K50 E52 T66 C67 G74 L75 R135 Y139 R142 H146 T170 L176 Q179 I181 R184 L196 R199
BS03	ZN	M	C24 C27 C81 C84	C7 C10 C64 C67
BS04	ZN	M	C45 C48 C71 C74	C28 C31 C54 C57
BS05	ZN	M	C165 C173 C179 H183	C148 C156 C162 H166

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding
• GO:0046872 metal ion binding

External links

• PDB: RCSB:6qdv, PDBe:6qdv, PDBj:6qdv
• PDBsum: 6qdv
• PubMed: 30705154
• UniProt: Q9NW64|RBM22_HUMAN Pre-mRNA-splicing factor RBM22 (Gene Name=RBM22)