Structure of PDB 6pwx Chain M

Receptor sequence
>6pwxM (length=107) Species: 8355 (Xenopus laevis) [Search protein sequence]
AKAKTRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAE
ILELAGNAARDNKKTRIIPRHLQLAVRNDEELNKLLGRVTIAQGGVLPNI
QSVLLPK
3D structure
PDB6pwx Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
ChainM
Resolution4.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna M A14 K15 T16 R17 R20 G28 R29 R32 R77 A3 K4 T5 R6 R9 G17 R18 R21 R66
BS02 dna M R29 R42 V43 G44 A45 K75 T76 R77 R18 R31 V32 G33 A34 K64 T65 R66
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:6pwx, PDBe:6pwx, PDBj:6pwx
PDBsum6pwx
PubMed31804488
UniProtP06897|H2A1_XENLA Histone H2A type 1

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