Structure of PDB 6mnf Chain M

Receptor sequence

>6mnfM (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]

EVQLVESGGGLVKAGGSLILSCGVSNFRISAHTMNWVRRVPGGGLEWVAS
ISTSSTYRDYADAVKGRFTVSRDDLEDFVYLQMHKMRVEDTAIYYCARKG
SDRLSDNDPFDAWGPGTVVTVSPASTKGPSVFPLAPSSKSTSGGTAALGC
LVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLG
TQTYICNVNHKPSNTKVDKKVEPK

3D structure

PDB

6mnf Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12.

Chain

Resolution

2.758 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	M	A31 S100A D100B	A31 S105 D106	PDBbind-CN: -logKd/Ki=5.89,Kd=1.3uM
BS02	MAN	M	A31 H32 T33 K95 G96 S100A D100B N100C D100D	A31 H32 T33 K99 G100 S105 D106 N107 D108	PDBbind-CN: -logKd/Ki=5.89,Kd=1.3uM

External links

PDB	RCSB:6mnf, PDBe:6mnf, PDBj:6mnf
PDBsum	6mnf
PubMed	16174734

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