Structure of PDB 6ef3 Chain M

Receptor sequence
>6ef3M (length=371) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
LDNEIRIFRSELQRLSHENNVMLEKIKDNKEKIKNNRQLPYLVANVVEVM
DKAAVVKTSSRQTVFLPMVGLVDPDKLKPNDLVGVNKDSYLILDTLPSEF
DSRVKAMEVDEKPTETYSDVGGLDKQIEELVEAIVLPMKRADKFKDMGIR
APKGALMYGPPGTGKTLLARACAAQTNATFLKLAAPQLVQMYIGEGAKLV
RDAFALAKEKAPTIIFIDELDAIGTKRFDSEKSGDREVQRTMLELLNQLD
GFSSDDRVKVLAATNRVDVLDPALLRSGRLDRKIEFPLPSEDSRAQILQI
HSRKMTTDDDINWQELARSTDEFNGAQLKAVTVEAGMIALRNGQSSVKHE
DFVEGISEVQARKSKSVSFYA
3D structure
PDB6ef3 Substrate-engaged 26Sproteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation.
ChainM
Resolution4.17 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP M G184 G225 T226 G227 K228 T229 L230 N328 I360 H364 G388 A389 K392 G121 G162 T163 G164 K165 T166 L167 N265 I297 H301 G325 A326 K329
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0036402 proteasome-activating activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010604 positive regulation of macromolecule metabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0070682 proteasome regulatory particle assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ef3, PDBe:6ef3, PDBj:6ef3
PDBsum6ef3
PubMed30309908
UniProtP33297|PRS6A_YEAST 26S proteasome regulatory subunit 6A (Gene Name=RPT5)

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