Structure of PDB 6d6r Chain M

Receptor sequence

>6d6rM (length=709) Species: 9606 (Homo sapiens) [Search protein sequence]

MPRVKVQSVETVEGCTHEVALPAEEDYLPLKPRVGKAAKEYPFILDAFQR
EAIQCVDNNQSVLVSAHTSAGKTVCAEYAIALALREKQRVIFTSPIKALS
NQKYREMYEEFQDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEVMRE
VAWVIFDEIHYMRDSERGVVWEETIILLPDNVHYVFLSATIPNARQFAEW
ICHLHKQPCHVIYTDYRPTPLQHYIFPAGGDGLHLVVDENGDFREDNFNT
AMQVLRDAGSNVFKIVKMIMERNFQPVIIFSFSKKDCEAYALQMTKLDFN
TDEEKKMVEEVFSNAIDCLSDEDKKLPQVEHVLPLLKRGIGIHHGGLLPI
LKETIEILFSEGLIKALFATETFAMGINMPARTVLFTNARKFDGKDFRWI
SSGEYIQMSGRAGRRGMDDRGIVILMVDEKMSPTIGKQLLKGSADPLNSA
FHLTYNMVLNLLRVEEINPEYMLEKSFYQFQHYRAIPGVVEKVKNSEDIK
SAKRELKKARTVLQMDELKCRKRVLRRLGFATSSDVIEMKGRVACEISSA
DELLLTEMMFNGLFNDLSAEQATALLSCFVFQENSSEMPKLTEQLAGPLR
QMQECAKRIAKVSAEAKLEIDEETYLSSFKPHLMDVVYTWATGATFAHIC
KMTDVFEGSIIRCMRRLEELLRQMCQAAKAIGNTELENKFAEGITKIKRD
IVFAASLYL

3D structure

PDB

6d6r Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.

Chain

Resolution

3.45 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	M	K192 T213 G214 T217 E230 I231 M235 R238 R262 K396 G457 E483 F504 F509 S882 N917 R995 R999 E1002 Q1009	K97 T118 G119 T122 E135 I136 M140 R143 R167 K284 G345 E371 F392 F397 S549 N584 R662 R666 E669 Q676
BS02	ANP	M	F138 G166 K167 T168 N490 R527	F43 G71 K72 T73 N378 R415

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity

	Biological Process
GO:0000398	mRNA splicing, via spliceosome
GO:0000460	maturation of 5.8S rRNA
GO:0006364	rRNA processing
GO:0006397	mRNA processing
GO:0006401	RNA catabolic process
GO:0006974	DNA damage response
GO:0008380	RNA splicing
GO:0016076	snRNA catabolic process

	Cellular Component
GO:0000176	nuclear exosome (RNase complex)
GO:0000178	exosome (RNase complex)
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005730	nucleolus
GO:0016607	nuclear speck
GO:0031499	TRAMP complex
GO:0071013	catalytic step 2 spliceosome

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Molecular Function

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Cellular Component

External links

PDB	RCSB:6d6r, PDBe:6d6r, PDBj:6d6r
PDBsum	6d6r
PubMed	29906447
UniProt	P42285\|MTREX_HUMAN Exosome RNA helicase MTR4 (Gene Name=MTREX)

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