Structure of PDB 6cse Chain M

Receptor sequence
>6cseM (length=431) Species: 267377 (Methanococcus maripaludis S2) [Search protein sequence]
WGPYMLVLLLGTGIFLTLRLGFMQIHTLPYALKLAFSKETSEGDISHFQA
LMTALAATIGTGNIAGVATAYVLGGPGAIFWMWVTAFFGMATKYAEAVLA
IKYRTVDDNGEMAGGPMYFLEKGLPLGKILGVAFAFFGAFAAFGIGNMVQ
TNSVADAVASNFGVDPLITGFVLAIFTAAVILGGIKSIGKATGIIVPFMA
VFYILAGLVILAMNIGYIIPAFGTIFSSAFNFSAGFGALIGTAIMWGVKR
GVFSNEAGLGSAPIAAAAAKTDHPGRQALVSMTGTFLDTIVVCTITGLVL
TIAGLKAFPGLTDLTGASLTAASFDALMPMGGLIVTIGLVFFAYSTVLGW
SYYGEKCFEYLIGTKGIRLYRIAFVLVAFWGATASLPLVWNIADTLNGAM
AIPNLIGLLLLSGVVVSETKAFNEIRKNEAK
3D structure
PDB6cse Structural basis for substrate binding and specificity of a sodium-alanine symporter AgcS.
ChainM
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA M T75 I76 N80 S274 D308 T58 I59 N63 S254 D288
BS02 ALA M A74 T75 G77 N80 Q170 F273 S274 E276 A57 T58 G60 N63 Q150 F253 S254 E256 PDBbind-CN: -logKd/Ki=5.60,Kd=2.5uM
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015293 symporter activity
Biological Process
GO:0003333 amino acid transmembrane transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6cse, PDBe:6cse, PDBj:6cse
PDBsum6cse
PubMed30659158
UniProtQ6LX42|AGCS_METMP Sodium/alanine symporter AgcS (Gene Name=agcS)

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