Structure of PDB 5x51 Chain M

Receptor sequence
>5x51M (length=1386) Species: 644223 (Komagataella phaffii GS115) [Search protein sequence]
YSSAPLRSVKEVQFGLLSPEEIRAISVVKIEYPEIMDESRQRPREGGLND
PKLGSIDRNFKCQTCGEGMAECPGHFGHMELAKPVFHIGFIPKIKKVCEC
ICMNCGKLLLDETNPTMAQAIRIRDPKKRFNAVWQLCKTKMVCEARGGCG
NTQPVVRKDGMKLWGTWKDAQPERKLLEILNVFKHISPEDCFRLGFNEDY
ARPEWMIITVLPVPPPQVRPSIAMDETTQGQDDLTHKLSDILKANINVQK
LEMDGSPQHIINEVEQLLQFHVATYMDNDIAGQPQALQKSGRPVKAIRAR
LKGKEGRLRGNLMGKRVFSARTVISGDPNLELDQVGVPISIAKTLSYPET
VTQYNIHRLTEYVRNGPNEHPGAKYVIRDNGDRIDLRYHKRAGDIVLQYG
WKVERHLMDDDPVLFNRQPSLHKMSMMAHRVKVMPYSTFRLNLSVTSPYN
ADFDGDEMNLHVPQSEETRAELSQLCAVPLQIVSPQSNKPVMGIVQDTLC
GVRKMTLRDTFIEYEQVMNMLFWVPSWDGVVPQPAILKPKPLWTGKQLLS
IAIPSGIHLQRTDGGNSLLSPKDNGMLIVDGKVMFGVVDKKTVGSGGGGL
IHTVMREKGPKICAELFGNIQKVVNYWLLHNGFSIGIGDAIADASTMKEI
THAISSAKEQVQEIIYKAQHNELELKPGMTLRESFEGEVSRTLNDARDSA
GRSAEMNLKDLNNVKQMVSAGSKGSFINIAQMSACVGQQMVEGKRIAFGF
ADRSLPHFTKDDFSPESKGFVENSYLRLTPQEFFFHAMAGREGLIDTAVK
TAETGYIQRRLVKALEDIMVHYDGTTRNSLGDIIQFLYGEDGLDGTQVER
QTIDTIPGSDKAFHKRYYVDLMDEKNSIKPDVIEYAADILGDVELQKELN
SEYEQLVSDRKFLRVFVNGDHNWPLPVNLRRIIQNAQQIFHLDRAKASDL
TIPEIIHGVRDLCKKLFVLRGENELIKEAQQNATSLFQCLVRARLATRRI
LEEFRLNRDAFEWVLGTIEAQFQRSLVHPGEMVGVIAAQSIGEPATQMTL
NTFHVTLGVPRLKEILNVAKNIKTPALTVYLDREIALDIEKAKVIQSSIY
TTLKNVTSATEIYYDPDPTSTVIEEDFDTVEAYFSIQSPWLLRLELDRAR
MLDKQLTMNQVADKISEVFSDDLFVMWSEDNADKLIIRCRVIAEEDQMLK
RIEAHMLDLIALRPGISKVYMVKHKVSVPDESGEYKNEELWALETDGINL
AEVMAVPGVDSSRTYSNSFVEILSVLGIEATRSSLYKEILNVIAFDGSYV
NYRHMALLVDVMTSRGYLMAITRHGINRADTALMRCSFEETVEILFEAGA
AAELDDCRGVSENVMLGQLAPMGTGAFDVMIDEKLL
3D structure
PDB5x51 Crystal structure of RNA polymerase II from Komagataella pastoris
ChainM
Resolution6.996 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN M C107 C110 C148 C102 C105 C143
BS02 ZN M C77 H80 C72 H75
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5x51, PDBe:5x51, PDBj:5x51
PDBsum5x51
PubMed28412353
UniProtC4R4Y0

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