Structure of PDB 5nfy Chain M

Receptor sequence

>5nfyM (length=132) Species: 229992 (SARS coronavirus Frankfurt 1)

HAGNATEVPANSTVLSFCAFAVDPAKAYKDYLASGGQPITNCVKMLCTHT
GTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFCDLKGKYVQI
PTTCANDPVGFTLRNTVCTVCGMWKGYGCSCD

3D structure

• PDB: 5nfy Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.
• Chain: M
• Resolution: 3.382 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
  2.1.1.57: methyltransferase cap1.
  2.7.7.48: RNA-directed RNA polymerase.
  2.7.7.50: mRNA guanylyltransferase.
  3.1.13.-
  3.4.19.12: ubiquitinyl hydrolase 1.
  3.4.22.-
  3.4.22.69: SARS coronavirus main proteinase.
  3.6.4.12: DNA helicase.
  3.6.4.13: RNA helicase.
  4.6.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	M	C74 C77 H83 C90	C75 C78 H84 C91

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0008270 zinc ion binding

Biological Process

• GO:0019079 viral genome replication

External links

• PDB: RCSB:5nfy, PDBe:5nfy, PDBj:5nfy
• PDBsum: 5nfy
• PubMed: 29279395
• UniProt: P0C6X7|R1AB_SARS Replicase polyprotein 1ab (Gene Name=rep)