Structure of PDB 5flv Chain M

Receptor sequence
>5flvM (length=229) Species: 10090 (Mus musculus) [Search protein sequence]
VLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYK
SKRQGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKT
KYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHW
MRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADAFSTHVFPE
TAFIAVTSYQNHKITQLKIENNPFAKGFR
3D structure
PDB5flv Complex Interdependence Regulates Heterotypic Transcription Factor Distribution and Coordinates Cardiogenesis.
ChainM
Resolution3.005 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna M F144 Q180 I183 W184 N187 K191 N1162 S1175 T1215 P1231 F1232 K1234 G1235 F3 Q39 I42 W43 N46 K50 N164 S177 T207 P223 F224 K226 G227 PDBbind-CN: Kd~50nM
BS02 dna M Y161 Q186 R189 Y190 R1081 R1082 K1159 Y1217 T1223 N1230 F1232 F1236 Y20 Q45 R48 Y49 R83 R84 K161 Y209 T215 N222 F224 F228 PDBbind-CN: Kd~50nM
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5flv, PDBe:5flv, PDBj:5flv
PDBsum5flv
PubMed26875865
UniProtP42582;
P70326

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