Structure of PDB 5epi Chain M

Receptor sequence

>5epiM (length=703) Species: 1601067 (Influenza B virus (B/Memphis/13/2003))

SMDTFITRNFQTTIIQKAKNTMAEFSEDPELQPAMLFNICVHLEVCYVIS
DMNFLDEEGKAYTARPQYEVIEGMPRTIAWMVQRSLAQEHGIETPKYLAD
LFDYKTKRFIEVGITKGLADDYFWKKKEKLGNSMELMIFSYNQDYSLSNE
SSLDEEGKGRVLSRLTELQAELSLKNLWQVLIGEEDIDFKLGQTISRLRD
ISVPAGFSNFEGMRSYIDNIDPKGAIERNLARMSPLVSVTPKKLTWEDLR
PIGPHIYNHELPEVPYNAFLLMSDELGLANMTEGKSKKPKTLAKECLEKY
STLRDQTDPILIMKSEKANENFLWKLWRDCVNTISNEEMSNELQKTNYAK
WATGDGLTYQKIMKEVAIDDETMCQEEPKIPNKCRVAAWVQTEMNLLSTL
TSKRALDLPEIGPDVAPVEHVGSERRKYFVNEINYCKASTVMMKYVLFHT
SLLNESNASMGKYKVIPITNRVVNEKGESFDMLYGLAVKGQSHLRGDTDV
VTVVTFEFSSTDPRVDSGKWPKYTVFRIGSLFVSGREKSVYLYCRVNGTN
KIQMKWGMEARRCLLQSMQQMEAIVEQESSIQGYDMTKACFKGDRVNSPK
TFSIGTQEGKLVKGSFGKALRVIFTKCLMHYVFGNAQLEGFSAESRRLLL
LIQALKDRKGPWVFDLEGMYSGIEECISNNPWVIQSAYWFNEWLGFEKEG
SKV

3D structure

• PDB: 5epi Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains.
• Chain: M
• Resolution: 4.1 Å

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	M	T366 G367 G369 L370 T371 Y372 H506 V513 R558 V559 N560 G561	T353 G354 G356 L357 T358 Y359 H493 V500 R545 V546 N547 G548

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:5epi, PDBe:5epi, PDBj:5epi
• PDBsum: 5epi
• PubMed: 26711008
• UniProt: Q5V8Z9