Structure of PDB 4tyd Chain M

Receptor sequence
>4tydM (length=195) Species: 11104 (Hepatitis C virus (isolate 1)) [Search protein sequence]
APITAYSQQTRGLLGCIITSLTGRDRNQVEGEVQVVSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWQAPPGARSLTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHA
VGIFRAAVCTRGVAKAVDFVPVESMETTMRASKGSVVIVGRIILS
3D structure
PDB4tyd Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.
ChainM
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3EO M P131 V132 S133 Y134 P131 V132 S133 Y134
BS02 ZN M C97 C99 C145 C97 C99 C145
BS03 3EO M Q41 Y56 H57 D81 V132 L135 K136 G137 S139 F154 R155 A157 Q41 Y56 H57 D81 V132 L135 K136 G137 S139 F154 R155 A157
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0019062 virion attachment to host cell
GO:0019087 transformation of host cell by virus
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4tyd, PDBe:4tyd, PDBj:4tyd
PDBsum4tyd
PubMed25155387
UniProtQ0ZNA6

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