Structure of PDB 4fx6 Chain M

Receptor sequence
>4fx6M (length=218) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence]
MDVMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAE
FRKRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRA
CLNVAEEMGREVFLLTEMSHPGAEMFIQGAADEIARMGVDLGVKNYVGPS
TRPERLSRLREIIGQDSFLISPGAGAQGGDPGETLRFADAIIVGASIYLA
DNPAAAAAGIIESIKDLL
3D structure
PDB4fx6 Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.
ChainM
Resolution1.531 Å
3D
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Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMP M D20 K72 M126 S127 P180 Q185 G202 A203 D12 K64 M118 S119 P172 Q177 G194 A195
BS02 BMP M D75 I76 T79 D67 I68 T71
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:4fx6, PDBe:4fx6, PDBj:4fx6
PDBsum4fx6
PubMed23030629
UniProtO26232|PYRF_METTH Orotidine 5'-phosphate decarboxylase (Gene Name=pyrF)

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