Structure of PDB 3hnb Chain M

Receptor sequence
>3hnbM (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
SCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQ
VNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWT
LFFQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRME
VLGCEA
3D structure
PDB3hnb Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding.
ChainM
Resolution1.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 768 M K2258 Q2311 S2312 W2313 H2315 K86 Q139 S140 W141 H143 PDBbind-CN: -logKd/Ki=5.11,IC50=7.8uM
BindingDB: IC50=7800nM
External links
PDB RCSB:3hnb, PDBe:3hnb, PDBj:3hnb
PDBsum3hnb
PubMed20089867
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8)

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