Structure of PDB 3h0g Chain M

Receptor sequence
>3h0gM (length=1476) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
SGIQFSPSSVPLRRVEEVQFGILSPEEIRSMSVAKIEFPETMDESGQRPR
VGGLLDPRLGTIDRQFKCQTCGETMADCPGHFGHIELAKPVFHIGFLSKI
KKILECVCWNCGKLKIDSSNPKFNDTQRYRDPKNRLNAVWNVCKTKMVCD
TGLSAGSDNFDLSNPSANMGHGGCGAAQPTIRKDGLRLWGSWKRGKDESD
LPEKRLLSPLEVHTIFTHISSEDLAHLGLNEQYARPDWMIITVLPVPPPS
VRPSISVDGTSRGEDDLTHKLSDIIKANANVRRCEQEGAPAHIVSEYEQL
LQFHVATYMDNEIAGQPQALQKSGRPLKSIRARLKGKEGRLRGNLMGKRV
DFSARTVITGDPNLSLDELGVPRSIAKTLTYPETVTPYNIYQLQELVRNG
PDEHPGAKYIIRDTGERIDLRYHKRAGDIPLRYGWRVERHIRDGDVVIFN
RQPSLHKMSMMGHRIRVMPYSTFRLNLSVTSPYNADFDGDEMNMHVPQSE
ETRAEIQEITMVPKQIVSPQSNKPVMGIVQDTLAGVRKFSLRDNFLTRNA
VMNIMLWVPDWDGILPPPVILKPKVLWTGKQILSLIIPKGINLIRDDDKQ
SLSNPTDSGMLIENGEIIYGVVDKKTVGASQGGLVHTIWKEKGPEICKGF
FNGIQRVVNYWLLHNGFSIGIGDTIADADTMKEVTRTVKEARRQVAECIQ
DAQHNRLKPEPGMTLRESFEAKVSRILNQARDNAGRSAEHSLKDSNNVKQ
MVAAGSKGSFINISQMSACVGQQIVEGKRIPFGFKYRTLPHFPKDDDSPE
SRGFIENSYLRGLTPQEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKAM
EDVMVRYDGTVRNAMGDIIQFAYGEDGLDATLVEYQVFDSLRLSTKQFEK
KYRIDLMEDRSLSLYMENSIENDSSVQDLLDEEYTQLVADRELLCKFIFP
KGDARWPLPVNVQRIIQNALQIFHLEAKKPTDLLPSDIINGLNELIAKLT
IFRGSDRITRDVQNNATLLFQILLRSKFAVKRVIMEYRLNKVAFEWIMGE
VEARFQQAVVSPGEMVGTLAAQSIGEPATQMTLNTFHYAGVSSKNVTLGV
PRLKEILNVAKNIKTPSLTIYLMPWIAANMDLAKNVQTQIEHTTLSTVTS
ATEIHYDPDPQDTVIEEDKDFVEAFFAIPDEEVEENLYKQSPWLLRLELD
RAKMLDKKLSMSDVAGKIAESFERDLFTIWSEDNADKLIIRCRIIRDDDR
KAEDDDNMIEEDVFLKTIEGHMLESISLRGVPNITRVYMMEHKIVRQIED
GTFERADEWVLETDGINLTEAMTVEGVDATRTYSNSFVEILQILGIEATR
SALLKELRNVIEFDGSYVNYRHLALLCDVMTSRGHLMAITRHGINRAETG
ALMRCSFEETVEILMDAAASGEKDDCKGISENIMLGQLAPMGTGAFDIYL
DQDMLMNYMVDSGFVGSPDAAAFSPL
3D structure
PDB3h0g Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.
ChainM
Resolution3.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN M C175 A177 C174 A176
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0140463 chromatin-protein adaptor activity
Biological Process
GO:0006325 chromatin organization
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006368 transcription elongation by RNA polymerase II
GO:0006369 termination of RNA polymerase II transcription
GO:0006370 7-methylguanosine mRNA capping
GO:0030643 intracellular phosphate ion homeostasis
GO:0180034 co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex
GO:0016591 RNA polymerase II, holoenzyme

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3h0g, PDBe:3h0g, PDBj:3h0g
PDBsum3h0g
PubMed19458260
UniProtP36594|RPB1_SCHPO DNA-directed RNA polymerase II subunit rpb1 (Gene Name=rpb1)

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