Structure of PDB 1ycp Chain M

Receptor sequence
>1ycpM (length=101) Species: 9913 (Bos taurus) [Search protein sequence]
VQPSVLQVVNLPLVERPVCKASTRIRITDNMFCAGYKPGEGKRGDACEGD
SGGPFVMKSPYNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI
D
3D structure
PDB1ycp Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
ChainM
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide M N159 K202 P204 N205 R206 W207 N10 K58 P60 N63 R64 W65
BS02 peptide M I174 D189 E192 S195 W215 G216 G219 I25 D45 E48 S51 W73 G74 G76
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ycp, PDBe:1ycp, PDBj:1ycp
PDBsum1ycp
PubMed9307032
UniProtP00735|THRB_BOVIN Prothrombin (Gene Name=F2)

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