Structure of PDB 1s4d Chain M

Receptor sequence
>1s4dM (length=252) Species: 43306 (Pseudomonas denitrificans (nom. rej.)) [Search protein sequence]
PALEKGSVWLVGAGPGDPGLLTLHAANALRQADVIVHDALVNEDCLKLAR
PGAVLEFAGKRGGPSPKQRDISLRLVELARAGNRVLRLKGGDPFVFGRGG
EEALTLVEHQVPFRIVPGITAGIGGLAYAGIPVTHREVNHAVTFLTGHDR
INWQGIASGSPVIVMYMAMKHIGAITANLIAGGRSPDEPVAFVCNAATPQ
QAVLETTLARAEADVAAAGLEPPAIVVVGEVVRLRAALDWIGALDGRKLA
AD
3D structure
PDB1s4d Structure/Function Studies on a S-Adenosyl-l-methionine-dependent Uroporphyrinogen III C Methyltransferase (SUMT), a Key Regulatory Enzyme of Tetrapyrrole Biosynthesis
ChainM
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.107: uroporphyrinogen-III C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH M P24 G100 G101 D102 V105 T130 A131 Y183 M184 A213 P240 A241 I242 P15 G90 G91 D92 V95 T120 A121 Y166 M167 A196 P223 A224 I225
Gene Ontology
Molecular Function
GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0009236 cobalamin biosynthetic process
GO:0019354 siroheme biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1s4d, PDBe:1s4d, PDBj:1s4d
PDBsum1s4d
PubMed15522295
UniProtP21631|SUMT_SINSX Uroporphyrinogen-III C-methyltransferase (Gene Name=cobA)

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