Structure of PDB 1owr Chain M

Receptor sequence
>1owrM (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
VPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQ
LHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVG
NTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRL
VFRVHIPESSGRIVSLQTASNPIECSQRSAHELPMVERQDTDSCLVYGGQ
QMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPE
YRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPV
3D structure
PDB1owr Structure of NFAT Bound to DNA as a Monomer
ChainM
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna M R421 G428 S429 R430 I479 R537 Q571 R665 R27 G34 S35 R36 I85 R143 Q177 R271 PDBbind-CN: Kd=2.7nM
BS02 dna M Y424 T426 E427 K520 R522 N523 R537 K538 T616 H672 Y30 T32 E33 K126 R128 N129 R143 K144 T222 H278 PDBbind-CN: Kd=2.7nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1owr, PDBe:1owr, PDBj:1owr
PDBsum1owr
PubMed14643663
UniProtQ13469|NFAC2_HUMAN Nuclear factor of activated T-cells, cytoplasmic 2 (Gene Name=NFATC2)

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