Structure of PDB 1gq2 Chain M

Receptor sequence
>1gq2M (length=555) Species: 8932 (Columba livia) [Search protein sequence]
KKGYEVLRDPHLNKGMAFTLEERQQLNIHGLLPPCFLGQDAQVYSILKNF
ERLTSDLDRYILLMSLQDRNEKLFYKVLTSDIERFMPIVYTPTVGLACQH
YGLAFRRPRGLFITIHDRGHIATMLQSWPESVIKAIVVTDGERILGLGDL
GCYGMGIPVGKLALYTACGGVKPHQCLPVMLDVGTDNETLLKDPLYIGLR
HKRIRGQAYDDLLDEFMEAVTSRYGMNCLIQFEDFANANAFRLLHKYRNK
YCTFNDDIQGTASVAVAGLLAALRITKNRLSDHTVLFQGAGEAALGIANL
IVMAMQKEGVSKEEAIKRIWMVDSKGLIVKGRASLTPEKEHFAHEHCEMK
NLEDIVKDIKPTVLIGVAAIGGAFTQQILQDMAAFNKRPIIFALSNPTSK
AECTAEQLYKYTEGRGIFASGSPFDPVTLPSGQTLYPGQGNNSYVFPGVA
LGVISCGLKHIGDDVFLTTAEVIAQEVSEENLQEGRLYPPLVTIQQVSLK
IAVRIAKEAYRNNTASTYPQPEDLEAFIRSQVYSTDYNCFVADSYTWPEE
AMKVK
3D structure
PDB1gq2 Structural Studies of the Pigeon Cytosolic Nadp+ -Dependent Malic Enzyme
ChainM
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y112 R165 K183 E255 D256 D278 D279 N421
Catalytic site (residue number reindexed from 1) Y90 R143 K161 E233 D234 D256 D257 N396
Enzyme Commision number 1.1.1.40: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP M R165 L167 G168 N259 T283 Q310 A312 G313 E314 A315 D345 S346 K362 A393 L419 N421 N466 N467 R143 L145 G146 N237 T261 Q288 A290 G291 E292 A293 D323 S324 K339 A368 L394 N396 N441 N442
BS02 OXL M L167 K183 N421 N467 L145 K161 N396 N442
BS03 MN M E255 D256 D279 E233 D234 D257
Gene Ontology
Molecular Function
GO:0004470 malic enzyme activity
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
GO:0008948 oxaloacetate decarboxylase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006108 malate metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1gq2, PDBe:1gq2, PDBj:1gq2
PDBsum1gq2
PubMed11790843
UniProtP40927|MAOX_COLLI NADP-dependent malic enzyme (Gene Name=ME1)

[Back to BioLiP]