Structure of PDB 1c9b Chain M

Receptor sequence
>1c9bM (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
SDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAI
ASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLI
TTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIY
MASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTP
VDKLPQL
3D structure
PDB1c9b Structural basis of preinitiation complex assembly on human pol II promoters.
ChainM
Resolution2.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna M Y259 T270 Q271 R286 L316 Y150 T161 Q162 R177 L207
BS02 dna M K189 K196 K80 K87
BS03 dna M K152 R154 K178 R193 G247 S249 S252 V280 A281 T284 K43 R45 K69 R84 G138 S140 S143 V171 A172 T175
Gene Ontology
Molecular Function
GO:0017025 TBP-class protein binding
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0070897 transcription preinitiation complex assembly

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Molecular Function
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Biological Process
External links
PDB RCSB:1c9b, PDBe:1c9b, PDBj:1c9b
PDBsum1c9b
PubMed10619841
UniProtQ00403|TF2B_HUMAN Transcription initiation factor IIB (Gene Name=GTF2B)

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