Structure of PDB 8xt3 Chain Lw

Receptor sequence
>8xt3Lw (length=132) Species: 9606 (Homo sapiens) [Search protein sequence]
YPRFVESVDEYQFVERLLPATRIPDPPKHEHYPTPSGWQPPRDPPPNLPY
FVRRSRMHNIPVYKDITHGNRQMTVIRKVEGDIWALQKDVEDFLSPLLGK
TPVTQVNEVTGTLRIKGYFDQELKAWLLEKGF
3D structure
PDB8xt3 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLw
Resolution3.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Lw S89 R90 M91 N93 Y97 K98 T101 H102 N104 R105 R111 T144 K150 S55 R56 M57 N59 Y63 K64 T67 H68 N70 R71 R77 T110 K116
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8xt3, PDBe:8xt3, PDBj:8xt3
PDBsum8xt3
PubMed38942792
UniProtQ13405|RM49_HUMAN Large ribosomal subunit protein mL49 (Gene Name=MRPL49)

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