Structure of PDB 8k2c Chain Lt

Receptor sequence
>8k2cLt (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
PNEIKVVYLRCTGGEVGATSALAPKIGPLGLSPKKVGDDIAKATGDWKGL
RITVKLTIQNRQAQIEVVPSASALIIKALKEITFDEIVNIARQMRHRSLA
RELSGTIKEILGTAQSVGCNVDGRHPHDIIDDINSGAVECP
3D structure
PDB8k2c Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLt
Resolution2.4 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Lt R16 S26 R57 A77 S78 A79 K83 L121 A122 R123 E124 T128 E131 I132 T135 A136 S138 R10 S20 R51 A71 S72 A73 K77 L99 A100 R101 E102 T106 E109 I110 T113 A114 S116
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0045202 synapse
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8k2c, PDBe:8k2c, PDBj:8k2c
PDBsum8k2c
PubMed38942792
UniProtP30050|RL12_HUMAN Large ribosomal subunit protein uL11 (Gene Name=RPL12)

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