Structure of PDB 8xt3 Chain Lr

Receptor sequence
>8xt3Lr (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
VKKGFRAAFRFQKELERQRLLRCPPPPVRRSEKPNWDYHAEIQAFGHRLQ
ENFSLDLLKTAFVNSCYIKSEEAKRQQLKSNQELSEQGTSFSQTCLTQFL
EDEYPDMPTEGIKNLVDFLTGEEVVCHVARNLAVEQLTLSEEFPVPPAVL
QQTFFAVIGALLQSSGPERTALFIRDFLITQMTGKELFEMWKIINPMGLL
VEELKKRNVSAPESRLTRQSGGTTALPLYFVGLYCDKKLIAEGPGETVLV
AEEEAARVALRKLYGFTENRRPWNY
3D structure
PDB8xt3 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLr
Resolution3.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Lr V31 K33 G34 F35 R36 F39 L45 R49 R52 V1 K3 G4 F5 R6 F9 L15 R19 R22
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
Biological Process
GO:0032543 mitochondrial translation
GO:0070125 mitochondrial translational elongation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0016604 nuclear body
GO:0070877 microprocessor complex
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt3, PDBe:8xt3, PDBj:8xt3
PDBsum8xt3
PubMed38942792
UniProtQ9H9J2|RM44_HUMAN Large ribosomal subunit protein mL44 (Gene Name=MRPL44)

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