Structure of PDB 8k2c Chain Lr

Receptor sequence

>8k2cLr (length=125) Species: 9606 (Homo sapiens) [Search protein sequence]

SAHLQWMVVRNCSSFLIKRNKQTYSTEPNNLKARNSFRYNGLIHRKTVGV
EPAADGKGVVVVIKRRSGQRKPATSYVRTTINKNARATLSSIRHMIRKNK
YRPDLRMAAIRRASAILRSQKPVMV

3D structure

PDB

8k2c Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Lr	W7 R11 N12 S15 K19 R20 K22 Q23 T24 R35 N36 S37 F38 R39 R46 K47 R66 R67 S68 T80 K84 N85 R87 S92 R94 H95 M96 R98 K99 N100 D105 R107 M108 R112	W6 R10 N11 S14 K18 R19 K21 Q22 T23 R34 N35 S36 F37 R38 R45 K46 R65 R66 S67 T79 K83 N84 R86 S91 R93 H94 M95 R97 K98 N99 D104 R106 M107 R111

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0030425	dendrite
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0044297	cell body
GO:0045202	synapse
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8k2c, PDBe:8k2c, PDBj:8k2c
PDBsum	8k2c
PubMed	38942792
UniProt	P46779\|RL28_HUMAN Large ribosomal subunit protein eL28 (Gene Name=RPL28)