Structure of PDB 8xt1 Chain Lq

Receptor sequence
>8xt1Lq (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
TARGTPSRFLASVLHNGLGRYVQQLQRLSFSVSRDGASSRGAREFVEREV
IDFARRNPGVVIYVNSRPCCVPRVVAEYLNGAVREESIHCKSVEEISTLV
QKLADQSGLDVIRIRKPFHTDNPSIQGQWHPFTNKPTTFRGLRPREVQ
3D structure
PDB8xt1 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLq
Resolution3.1 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Lq T2 A3 R4 D36 S39 P69 C70 C71 V72 R74 H90 R114 R116 K117 T1 A2 R3 D35 S38 P68 C69 C70 V71 R73 H89 R113 R115 K116
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Cellular Component
External links
PDB RCSB:8xt1, PDBe:8xt1, PDBj:8xt1
PDBsum8xt1
PubMed38942792
UniProtQ8N983|RM43_HUMAN Large ribosomal subunit protein mL43 (Gene Name=MRPL43)

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