Structure of PDB 6y6x Chain Lp

Receptor sequence

>6y6xLp (length=91) Species: 9606 (Homo sapiens) [Search protein sequence]

AKRTKKVGIVGKYGTRYGASLRKMVKKIEISQHAKYTCSFCGKTKMKRRA
VGIWHCGSCMKTVAGGAWTYNTTSAVTVKSAIRRLKELKDQ

3D structure

PDB

6y6x Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.

Chain

Resolution

2.8 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Lp	A2 R4 T5 K6 K7 V8 G9 I10 G12 K13 Y14 G15 T16 R17 Y18 G19 A20 S21 R23 H34 F41 C42 K44 K46 R50 A51 G58 S59 K62 W69	A1 R3 T4 K5 K6 V7 G8 I9 G11 K12 Y13 G14 T15 R16 Y17 G18 A19 S20 R22 H33 F40 C41 K43 K45 R49 A50 G57 S58 K61 W68
BS02	ZN	Lp	C39 C42 C57 C60	C38 C41 C56 C59

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0046872	metal ion binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:6y6x, PDBe:6y6x, PDBj:6y6x
PDBsum	6y6x
PubMed	32601485
UniProt	P61513\|RL37A_HUMAN Large ribosomal subunit protein eL43 (Gene Name=RPL37A)