Structure of PDB 8k2a Chain Lo

Receptor sequence
>8k2aLo (length=124) Species: 9606 (Homo sapiens) [Search protein sequence]
GADRMSKWTSKRGPRSFRGRKGRGAKGIGFLTSGWRFVQIKEMVPEFVVP
DLTGFKLKPYVSYLAPESEETPLTAAQLFSEAVAPAIEKDFKDGTFDPDN
LEKYGFEPTQEGKLFQLYPRNFLR
3D structure
PDB8k2a Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLo
Resolution2.9 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Lo R17 S23 K24 P27 R28 S29 F30 R31 G32 R33 K34 K39 G40 I41 L44 S46 W48 R49 F50 V51 Q52 R4 S10 K11 P14 R15 S16 F17 R18 G19 R20 K21 K26 G27 I28 L31 S33 W35 R36 F37 V38 Q39
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0006915 apoptotic process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:8k2a, PDBe:8k2a, PDBj:8k2a
PDBsum8k2a
PubMed38942792
UniProtQ8IXM3|RM41_HUMAN Large ribosomal subunit protein mL41 (Gene Name=MRPL41)

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