Structure of PDB 8xt0 Chain Ll

Receptor sequence
>8xt0Ll (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
RRTPPLGPMPNSDIDLSNLERLEKYRSFDRYRRRAEQEAQAPHWWRTYRE
YFGEKTDPKEKIDIGLPPPKVSRTQQLLERKQAIQELRANVEEERAARLR
TASVPLDAVRAEWERTCGPYHKQRLAEYYGLYRDLFHGATFVPRVPLHVA
YAVGEDDLMPVYCGNEVTPTEAAQAPEVTYEAEEGSLWTLLLTSLDGHLL
EPDAEYLHWLLTNIPGNRVAEGQVTCPYLPPFPARGSGIHRLAFLLFKQD
QPIDFSEDARPSPCYQLAQRTFRTFDFYKKHQETMTPAGLSFFQCRWDDS
VTYIFHQLLDMREPVFEFVRPPPYHPKQKRFPHRQPLRYLDRYRDSHEPT
YGIY
3D structure
PDB8xt0 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLl
Resolution3.2 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Ll R27 R28 R72 H351 P352 R356 H359 R360 R364 R368 T376 Y377 G378 I379 Y380 R1 R2 R46 H325 P326 R330 H333 R334 R338 R342 T350 Y351 G352 I353 Y354
BS02 rna Ll R52 S53 R56 R59 R99 K107 R114 R126 R26 S27 R30 R33 R73 K81 R88 R100
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005829 cytosol
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt0, PDBe:8xt0, PDBj:8xt0
PDBsum8xt0
PubMed38942792
UniProtQ96DV4|RM38_HUMAN Large ribosomal subunit protein mL38 (Gene Name=MRPL38)

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