Structure of PDB 7nrd Chain Ll

Receptor sequence

>7nrdLl (length=81) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

GKGTPSFGKRHNKSHTLCNRCGRRSFHVQKKTCSSCGYPAAKTRSYNWGA
KAKRRHTTGTGRMRYLKHVSRRFKNGFQTGS

3D structure

PDB

7nrd Structure of Gcn1 bound to stalled and colliding 80S ribosomes.

Chain

Resolution

4.36 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Ll	K3 T5 P6 S7 F8 G9 R11 H12 N13 S15 H16 R24 R25 H28 Q30 K43 T44 R45 Y47 N48 W49 K52 K54 R55 R56 T59	K2 T4 P5 S6 F7 G8 R10 H11 N12 S14 H15 R23 R24 H27 Q29 K42 T43 R44 Y46 N47 W48 K51 K53 R54 R55 T58
BS02	rna	Ll	R21 G23 F27 V29 K32 T59 G60 T61 G62 R63 M64 R65 Y66 L67 K68 V70 R72 R73 F74 K75 N76 Q79 T80 G81 S82	R20 G22 F26 V28 K31 T58 G59 T60 G61 R62 M63 R64 Y65 L66 K67 V69 R71 R72 F73 K74 N75 Q78 T79 G80 S81

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008270	zinc ion binding
GO:0019843	rRNA binding
GO:0046872	metal ion binding

	Biological Process
GO:0000448	cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0030687	preribosome, large subunit precursor
GO:0044391	ribosomal subunit
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7nrd, PDBe:7nrd, PDBj:7nrd
PDBsum	7nrd
PubMed	33790014
UniProt	P49166\|RL37A_YEAST Large ribosomal subunit protein eL37A (Gene Name=RPL37A)