Structure of PDB 8xt2 Chain Lk

Receptor sequence

>8xt2Lk (length=394) Species: 9606 (Homo sapiens)

AYEWGVRSTRKSEPPPLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWD
RGYKDPRFYRSPPLHEHPLYKDQACYIFHHRCRLLEGVKQALWLTKTKLI
EGLPEKVLSLVDDPRNHIENQDECVLNVISHARLWQTTEEIPKRETYCPV
IVDNLIQLCKSQILKHPSLARRICVQNSTFSATWNRESLLLQVRGSGGAR
LSTKDPLPTIASREEIEATKNHVLETFYPISPIIDLHECNIYDVKNDTGF
QEGYPYPYPHTLYLLDKANLRPHRLQPDQLRAKMILFAFGSALAQARLLY
GNDAKVLEQPVVVQSVGTDGRVFHFLVFQLNTTDLDCNEGVKNLAWVDSD
QLLYQHFWCLPVIKKRVVVEPVGPVGFKPETFRKFLALYLHGAA

3D structure

• PDB: 8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
• Chain: Lk
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Lk	Y31 E32 W33 V35 R36 S37 P44 F66 P68 R72 F75 W78 R80 R86 F87 Y88 R89 S90 L93 H108 R110 R112 R223 H266 I270 L299 R300 P301 H302 Q305 R350 Q384 H385 W387 C388 L389 K394 R395	Y2 E3 W4 V6 R7 S8 P15 F37 P39 R43 F46 W49 R51 R57 F58 Y59 R60 S61 L64 H79 R81 R83 R194 H237 I241 L270 R271 P272 H273 Q276 R321 Q355 H356 W358 C359 L360 K365 R366

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
• PDBsum: 8xt2
• PubMed: 38942792
• UniProt: Q9BZE1|RM37_HUMAN Large ribosomal subunit protein mL37 (Gene Name=MRPL37)