Structure of PDB 8xsy Chain Lk

Receptor sequence
>8xsyLk (length=69) Species: 9606 (Homo sapiens) [Search protein sequence]
PRKIEEIKDFLLTARRKDAKSVKIKKNKDNVKFKVRCSRYLYTLVITDKE
KAEKLKQSLPPGLAVKELK
3D structure
PDB8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLk
Resolution3.0 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Lk P2 R3 K4 R17 D19 K24 K26 N28 K33 K35 R37 S39 R40 Y41 L42 T44 L69 P1 R2 K3 R16 D18 K23 K25 N27 K32 K34 R36 S38 R39 Y40 L41 T43 L68
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006417 regulation of translation
GO:0007605 sensory perception of sound
GO:0022618 protein-RNA complex assembly
GO:0034463 90S preribosome assembly
GO:0042474 middle ear morphogenesis
GO:0048318 axial mesoderm development
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0014069 postsynaptic density
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0033291 eukaryotic 80S initiation complex
GO:0045202 synapse
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
PDBsum8xsy
PubMed38942792
UniProtP63173|RL38_HUMAN Large ribosomal subunit protein eL38 (Gene Name=RPL38)

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