Structure of PDB 8xsx Chain Lj

Receptor sequence

>8xsxLj (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPKPK

3D structure

PDB

8xsx Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	Lj	T2 K3 G4 T5 S6 S7 F8 G9 K10 R11 R12 N13 K14 T15 H16 K25 H28 Q30 K31 G35 K36 R43 K44 R45 K46 Y47 N48 W49 K52 R55 R56 T58 T59 Y71 R75	T1 K2 G3 T4 S5 S6 F7 G8 K9 R10 R11 N12 K13 T14 H15 K24 H27 Q29 K30 G34 K35 R42 K43 R44 K45 Y46 N47 W48 K51 R54 R55 T57 T58 Y70 R74
BS02	rna	Lj	R20 R21 C22 G23 Y39 K42 N57 T59 G60 G62 R63 M64 R65 H66 L67 Y71 R72 F74 H76 R79 E80 G81 T82 T83 P84 K85 K87	R19 R20 C21 G22 Y38 K41 N56 T58 G59 G61 R62 M63 R64 H65 L66 Y70 R71 F73 H75 R78 E79 G80 T81 T82 P83 K84 K86
BS03	ZN	Lj	C19 C34 C37	C18 C33 C36

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding
GO:0046872	metal ion binding
GO:0097371	MDM2/MDM4 family protein binding
GO:1990948	ubiquitin ligase inhibitor activity

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation
GO:1901798	positive regulation of signal transduction by p53 class mediator

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xsx, PDBe:8xsx, PDBj:8xsx
PDBsum	8xsx
PubMed	38942792
UniProt	P61927\|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)