Structure of PDB 8xsx Chain Lh

Receptor sequence

>8xsxLh (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]

AKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVR
KSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEEN
LKTKKQQRKERLYPLRKYAVKA

3D structure

PDB

8xsx Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Lh	K74 K77 Y78 R84 R89 R93 R94 K97 H98 K106 R109 R112	K73 K76 Y77 R83 R88 R92 R93 K96 H97 K105 R108 R111
BS02	rna	Lh	K3 A6 R10 K35 L44 S45 R48 R51 K52 A55 R56 L58 T59 N62 Q63 K66 R70 L81 K86 T88 R89 R92	K2 A5 R9 K34 L43 S44 R47 R50 K51 A54 R55 L57 T58 N61 Q62 K65 R69 L80 K85 T87 R88 R91

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xsx, PDBe:8xsx, PDBj:8xsx
PDBsum	8xsx
PubMed	38942792
UniProt	P42766\|RL35_HUMAN Large ribosomal subunit protein uL29 (Gene Name=RPL35)