Structure of PDB 7xnx Chain Lh

Receptor sequence

>7xnxLh (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]

AKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVR
KSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEEN
LKTKKQQRKERLYPLRKYAVKA

3D structure

PDB

7xnx A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.

Chain

Resolution

2.7 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Lh	R70 K77 Y78 K79 R84 R93 R94 L95 N96 K97 K106 R109 K110 R112	R69 K76 Y77 K78 R83 R92 R93 L94 N95 K96 K105 R108 K109 R111
BS02	rna	Lh	K5 R7 R10 A41 L44 S45 R48 R51 K52 A55 R56 L58 T59 N62 Q63 K66 R70 L81 R84 P85 K86 T88 R89 R92	K4 R6 R9 A40 L43 S44 R47 R50 K51 A54 R55 L57 T58 N61 Q62 K65 R69 L80 R83 P84 K85 T87 R88 R91

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7xnx, PDBe:7xnx, PDBj:7xnx
PDBsum	7xnx
PubMed	36259929
UniProt	P42766\|RL35_HUMAN Large ribosomal subunit protein uL29 (Gene Name=RPL35)