Structure of PDB 7qvp Chain Lh

Receptor sequence

>7qvpLh (length=121) Species: 9606 (Homo sapiens) [Search protein sequence]

KIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVRK
SIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEENL
KTKKQQRKERLYPLRKYAVKA

3D structure

PDB

7qvp A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

Chain

Resolution

3.0 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Lh	R70 Y78 K79 R84 R89 R93 N96 K97 H98 K106 R112 L113	R68 Y76 K77 R82 R87 R91 N94 K95 H96 K104 R110 L111
BS02	rna	Lh	K5 A6 R7 K35 L44 S45 R48 R51 K52 A55 R56 L58 T59 N62 Q63 K66 R70 L81 K86 T88 R89 R92	K3 A4 R5 K33 L42 S43 R46 R49 K50 A53 R54 L56 T57 N60 Q61 K64 R68 L79 K84 T86 R87 R90

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:7qvp, PDBe:7qvp, PDBj:7qvp
PDBsum	7qvp
PubMed	36302773
UniProt	P42766\|RL35_HUMAN Large ribosomal subunit protein uL29 (Gene Name=RPL35)