Structure of PDB 5lks Chain Lh

Receptor sequence

>5lksLh (length=122) Species: 9606 (Homo sapiens) [Search protein sequence]

AKIKARDLRGKKKEELLKQLDDLKVELSQLRVAKVTGGAASKLSKIRVVR
KSIARVLTVINQTQKENLRKFYKGKKYKPLDLRPKKTRAMRRRLNKHEEN
LKTKKQQRKERLYPLRKYAVKA

3D structure

PDB

5lks Structure-function insights reveal the human ribosome as a cancer target for antibiotics.

Chain

Resolution

3.6 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Lh	Y73 K74 G75 K77 R89 R94 N96 K97 H98 K106 R109 E111 R112	Y72 K73 G74 K76 R88 R93 N95 K96 H97 K105 R108 E110 R111
BS02	rna	Lh	A2 K5 A6 R10 K35 S45 R48 R51 K52 A55 L58 T59 N62 Q63 K66 L81 R84 T88 R89 R92	A1 K4 A5 R9 K34 S44 R47 R50 K51 A54 L57 T58 N61 Q62 K65 L80 R83 T87 R88 R91

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:5lks, PDBe:5lks, PDBj:5lks
PDBsum	5lks
PubMed	27665925
UniProt	P42766\|RL35_HUMAN Large ribosomal subunit protein uL29 (Gene Name=RPL35)