Structure of PDB 8xt2 Chain Lf

Receptor sequence
>8xt2Lf (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
AAPKNRRTIEVNRCRRRNPQKLIKVKNNIDVCPECGHLKQKHVLCAYCYE
KVCKETAEIRRQIGKQEGGPFKAPTIETVVLYTGETPSEQDQGKRIIERD
RKRPSWFT
3D structure
PDB8xt2 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
ChainLf
Resolution3.3 Å
3D
structure
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Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Lf A79 A80 P81 K82 N83 R84 R85 T86 I87 N90 R91 C92 R93 R94 R95 N96 P97 Q98 K99 N106 H120 R138 R139 G142 F149 A1 A2 P3 K4 N5 R6 R7 T8 I9 N12 R13 C14 R15 R16 R17 N18 P19 Q20 K21 N28 H42 R60 R61 G64 F71
BS02 ZN Lf C110 C113 C123 C32 C35 C45
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005761 mitochondrial ribosome
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8xt2, PDBe:8xt2, PDBj:8xt2
PDBsum8xt2
PubMed38942792
UniProtQ9BYC8|RM32_HUMAN Large ribosomal subunit protein bL32m (Gene Name=MRPL32)

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