Structure of PDB 8xsz Chain Lf

Receptor sequence

>8xszLf (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]

SGRLWSKAIFAGYKRGLRNQREHTALLKIEGVYARDETEFYLGKRCAYVY
KAKNNTVTPGGKPNKTRVIWGKVTRAHGNSGMVRAKFRSNLPAKAIGHRI
RVMLYPSRI

3D structure

PDB

8xsz Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

3.2 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Lf	S2 G3 R4 W6 K8 K15 R16 G17 L18 R19 N20 Q21 R22 E23 H24 K29 Y34 R36 L43 G44 Y51 K52 K54 N55 N56 T57 V58 P60 T67 R68 V69 W71 K73 T75 R76 H78 G79 N80 S81 R85 R89 S90 N91 P93 A94 K95 R100 R102	S1 G2 R3 W5 K7 K14 R15 G16 L17 R18 N19 Q20 R21 E22 H23 K28 Y33 R35 L42 G43 Y50 K51 K53 N54 N55 T56 V57 P59 T66 R67 V68 W70 K72 T74 R75 H77 G78 N79 S80 R84 R88 S89 N90 P92 A93 K94 R99 R101

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006364	rRNA processing
GO:0006412	translation
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8xsz, PDBe:8xsz, PDBj:8xsz
PDBsum	8xsz
PubMed	38942792
UniProt	P18077\|RL35A_HUMAN Large ribosomal subunit protein eL33 (Gene Name=RPL35A)