Structure of PDB 8xsy Chain Le

Receptor sequence

>8xsyLe (length=128) Species: 9606 (Homo sapiens)

AALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKG
QILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAH
NVSSKNRKAIVERAAQLAIRVTNPNARL

3D structure

• PDB: 8xsy Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
• Chain: Le
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Le	R5 K14 K15 R16 T17 K18 F20 R22 H23 Q24 D26 R27 Y28 V29 K30 I31 N34 W35 R36 K37 R39 G40 I41 D42 N43 R44 R46 R47 R48 F49 K50 G51 Q52 I53 P56 N57 I58 G59 Y60 G61 S62 N63 K64 K65 K67 H68 P71 L78 K83 E98 I99 A100 H101 N102 S104 S105 K106 N107 R108 N124 R128	R4 K13 K14 R15 T16 K17 F19 R21 H22 Q23 D25 R26 Y27 V28 K29 I30 N33 W34 R35 K36 R38 G39 I40 D41 N42 R43 R45 R46 R47 F48 K49 G50 Q51 I52 P55 N56 I57 G58 Y59 G60 S61 N62 K63 K64 K66 H67 P70 L77 K82 E97 I98 A99 H100 N101 S103 S104 K105 N106 R107 N123 R127
BS02	MG	Le	S25 Y28 V29 I31	S24 Y27 V28 I30

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8xsy, PDBe:8xsy, PDBj:8xsy
• PDBsum: 8xsy
• PubMed: 38942792
• UniProt: P62910|RL32_HUMAN Large ribosomal subunit protein eL32 (Gene Name=RPL32)