Structure of PDB 8k82 Chain Le

Receptor sequence

>8k82Le (length=127) Species: 4932 (Saccharomyces cerevisiae)

ASLPHPKIVKKHTKKFKRHHSDRYHRVAENWRKQKGIDSVVRRRFRGNIS
QPKIGYGSNKKTKFLSPSGHKTFLVANVKDLETLTMHTKTYAAEIAHNIS
AKNRVVILARAKALGIKVTNPKGRLAL

3D structure

• PDB: 8k82 Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.
• Chain: Le
• Resolution: 3.0 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Le	A2 K12 T14 K15 F17 R19 H21 D23 R24 Y25 H26 R27 V28 N31 W32 R33 K34 K36 G37 I38 D39 S40 R43 R44 R45 F46 R47 G48 N49 I50 P53 K54 I55 G56 Y57 G58 S59 N60 K61 K64 F65 P68 S69 K80 E95 A97 H98 N99 I100 S101 K103 N104 R105 K118 N121 G124 R125	A1 K11 T13 K14 F16 R18 H20 D22 R23 Y24 H25 R26 V27 N30 W31 R32 K33 K35 G36 I37 D38 S39 R42 R43 R44 F45 R46 G47 N48 I49 P52 K53 I54 G55 Y56 G57 S58 N59 K60 K63 F64 P67 S68 K79 E94 A96 H97 N98 I99 S100 K102 N103 R104 K117 N120 G123 R124

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8k82, PDBe:8k82, PDBj:8k82
• PDBsum: 8k82
• PubMed: 38942792
• UniProt: P38061|RL32_YEAST Large ribosomal subunit protein eL32 (Gene Name=RPL32)