Structure of PDB 8k2c Chain Le

Receptor sequence

>8k2cLe (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]

AALRPLVKPKIVKKRTKKFIRHQSDRYVKIKRNWRKPRGIDNRVRRRFKG
QILMPNIGYGSNKKTKHMLPSGFRKFLVHNVKELEVLLMCNKSYCAEIAH
NVSSKNRKAIVERAAQLAIRVTNPNARL

3D structure

PDB

8k2c Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

2.4 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Le	R5 K14 K15 R16 T17 K18 K19 F20 R22 H23 Q24 D26 Y28 V29 K30 I31 N34 W35 R36 K37 R39 G40 I41 D42 N43 R44 R46 R47 R48 F49 K50 G51 Q52 I53 P56 N57 I58 G59 Y60 G61 S62 N63 K64 K65 K67 H68 P71 K83 E98 A100 H101 N102 S104 S105 N107 N124 A127 R128	R4 K13 K14 R15 T16 K17 K18 F19 R21 H22 Q23 D25 Y27 V28 K29 I30 N33 W34 R35 K36 R38 G39 I40 D41 N42 R43 R45 R46 R47 F48 K49 G50 Q51 I52 P55 N56 I57 G58 Y59 G60 S61 N62 K63 K64 K66 H67 P70 K82 E97 A99 H100 N101 S103 S104 N106 N123 A126 R127
BS02	MG	Le	S25 Y28 I31	S24 Y27 I30

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8k2c, PDBe:8k2c, PDBj:8k2c
PDBsum	8k2c
PubMed	38942792
UniProt	P62910\|RL32_HUMAN Large ribosomal subunit protein eL32 (Gene Name=RPL32)