Structure of PDB 8yop Chain Ld

Receptor sequence

>8yopLd (length=107) Species: 9606 (Homo sapiens) [Search protein sequence]

NEVVTREYTINIHKRIHGVGFKKRAPRALKEIRKFAMKEMGTPDVRIDTR
LNKAVWAKGIRNVPYRIRVRLSRKRNEDEDSPNKLYTLVTYVPVTTFKNL
QTVNVDE

3D structure

PDB

8yop Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.

Chain

Resolution

2.2 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Ld	R23 T26 N28 H30 K31 R32 H34 G35 F38 K39 R41 L46 K47 R50 R63 I64 T66 N69 K70 W73 I77 R78 N79 Y82 R83 K115 N116 L117 Q118 T119 N121	R6 T9 N11 H13 K14 R15 H17 G18 F21 K22 R24 L29 K30 R33 R46 I47 T49 N52 K53 W56 I60 R61 N62 Y65 R66 K98 N99 L100 Q101 T102 N104

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding

	Biological Process
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0005925	focal adhesion
GO:0016020	membrane
GO:0022625	cytosolic large ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0070062	extracellular exosome
GO:1990904	ribonucleoprotein complex

External links

PDB	RCSB:8yop, PDBe:8yop, PDBj:8yop
PDBsum	8yop
PubMed	38942792
UniProt	P62899\|RL31_HUMAN Large ribosomal subunit protein eL31 (Gene Name=RPL31)